PEA (palmitoylethanolamide)
C18H37NO2
A long fatty-acid tail attached to a small head group. Your body makes it naturally in response to injury and inflammation.
Evidence current to September 2026
What it's pushed for
What the research shows
Across chronic pain conditions, a meta-analysis of 11 double-blind randomized trials (774 patients) found PEA lowered pain scores, with no major side effects reported.
For endometriosis, studies are small. One 30-person pilot found PEA plus polydatin reduced pain about as well as hormonal therapy without stopping ovulation. A review of the endometriosis studies noted they were low quality.
Myth vs. fact
Myth"PEA is proven for endometriosis."
FactIt's one of the more promising non-hormonal options, but most endometriosis studies were small and open-label, meaning patients knew what they were taking.
The detail most people miss
Many endometriosis studies tested PEA combined with polydatin, not PEA alone, and most used micronized or ultramicronized forms. A plain PEA product isn't the same thing that was studied.
Who should check with a clinician first
Anyone pregnant or trying to conceive, or on multiple medications. Tolerability in trials was good, but ask your clinician first.
What to look for on the label
Check the form (micronized or ultramicronized) and whether it's PEA alone or combined with polydatin.
How to read any supplement labelSources
This guide is for education, not medical advice. Supplements can interact with medications and health conditions. Talk with your clinician or pharmacist before starting, stopping, or changing anything. The Lily Perspective earns no income from any supplement brand or retailer.